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Mechanism of GR activation by GC and by SEGRA. FKBP indicates FK506 binding protein; GC, glucocorticoids; GR, glucocorticoid receptor; GRE, glucocorticoid responsive element; HSP, heat shock protein; nGRE, negative GRE; SEGRA, selective glucocorticoid receptor agonists; TF, transcription factor; TF-RE, complex of TF with responsive element.
