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. 2020 Dec 20;14:1178223420974667. doi: 10.1177/1178223420974667

Table 2.

Differences of GCs functions in ER+ and ER-BC.

BC subtype GC effects Result
Luminal (ER+) TR of AKT/mTOR, CCND1, CDK2, CDK6 Block the cytoskeleton organizations and cell migrations, inhibition of proliferation
Basal (TNBC) TA of ROR1, CDK1, MKP1, SGK1, PDK4, TSC22D, CCN5/WISP-2 and KLF9.
TR of Bid, CD95 L, TRAIL, Bcl-xL, IRS-1, PRAG1, PLK2, CDH11, HGF, ZNF703 and SOX9
Increase survival, proliferation, metastatic potential, tamoxifen resistance

Abbreviations: BC, breast cancer; Bcl-xL, BCL2-like 1; Bid, BH3 interacting domain death agonist; CCND1, cyclin D1; CCN5/WISP-2, cellular communication network factor 5; CDH11, cadherin 11; CDK1, cyclin-dependent kinase 1; CDK2, cyclin-dependent kinase 2; CDK6, cyclin-dependent kinase 6; CD95L, Fas ligand; ER, estrogen receptor; GC, glucocorticoid; HGF, hepatocyte growth factor; IRS1, insulin receptor substrate 1; KLF9, Kruppel-like factor 9; MKP1, mitogen-activated protein kinase phosphatase 1; mTOR, mammalian target of rapamycin; PDK4, pyruvate dehydrogenase kinase 4; PLK2, polo-like kinase 2; PRAG1, PEAK1-related, kinase-activating pseudokinase 1; ROR1, receptor-tyrosine-kinase-like orphan receptor 1; SGK1, serum/glucocorticoid-regulated kinase 1; SOX9, SRY-box transcription factor 9; TA, transactivation; TNBC, triple-negative breast cancer; TR, transrepression; TRAIL, TNF superfamily member 10; TSC22D, TSC22 domain family, member 3; ZNF703, zinc finger protein 703.