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. 2020 Dec 9;7:616768. doi: 10.3389/fmolb.2020.616768

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Copyright © 2020 Zhuang, Liu, Fu, Yuan, Luo, Huang, Yang, Xie and Zhuang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The schematic diagram of mechanism of lncRNA MIR497HG in BCa. E2F4 bound to the promoter of MIR497HG to act as inhibitory transcription factors to suppress the expression of MIR497HG. miR-497 and miR-195 were derived from MIR497HG, and they suppressed the crosstalk of Yap and SMAD3, which were key components in Hippo/Yap and TGF-β/Smad signaling. Then, the downstream of Yap/SMAD3 complex, oncogenic CTGF, was restrained to curb cell progression of BCa.