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Bixin attenuates the symptoms of EAE mice (A). Chemical structure of bixin (B). Study procedure (C). Body weight and (D) clinical behavior scores of the EAE mice (E). Representative images show behavioral symptoms of EAE mice in each group. Black arrows present limp tail or hind limb paralysis. Data shown in graphs represents the means ± SD (n = 5). **P < 0.01, vs. control group; ##P < 0.01, vs. EAE group.
