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. 2020 Dec 9;11:593368. doi: 10.3389/fimmu.2020.593368

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Copyright © 2020 Yu, Wu, Li, Deng, Liu, Zhang, He, Zhao and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bixin alleviates oxidative stress in EAE mice (A). The level of reactive oxygen species (ROS) in the brain and spinal cord tissues was assessed by DHE staining, and the quantitative results are shown. Scale bars: 100 μm (B). The protein level of 3-NT in the CNS tissues was assessed by western blotting, and the quantitative results are shown (C). The activities of SOD and (D) the levels of MDA in the serum. Data shown in graphs represents the means ± SD (n = 5). **P < 0.01, vs. control group; ^##P < 0.01, vs. EAE group.