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. 2020 Dec 9;11:593368. doi: 10.3389/fimmu.2020.593368

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Copyright © 2020 Yu, Wu, Li, Deng, Liu, Zhang, He, Zhao and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bixin activates the NRF2 signaling in EAE mice (A). The protein levels of NRF2 and downstream genes Catalase, NQO-1, and SOD2 in the brain tissues were assessed by western blotting, and the quantitative results are shown (B–E). mRNA expression of NRF2, Catalase, NQO-1, and SOD2 in the CNS tissues were quantitated by qRT-PCR. IHC of NRF2 in brain sections (F) (Scale bars: 50 μm) and spinal cord sections (G) (Scale bars: 100 μm). Data shown in graphs represents the means ± SD (n = 5). *P < 0.05, **P < 0.01, vs. control group or ML385 group; ^## P < 0.01, vs. EAE group or EAE + ML385 group.