Table 2.
Univariate and Multivariate Analyses of Prognostic Factors in HCC in Training Cohort
| Variables | OS | DFS | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| P | HR (95% CI) | P | P | HR (95% CI) | P | |||
| Gender | 0.93 | 0.57 | ||||||
| Age(years) | 0.46 | 0.08 | ||||||
| liver cirrhosis | 0.59 | 0.45 | ||||||
| Hepatitis history | 0.81 | 0.15 | ||||||
| BMI | 0.18 | 0.11 | ||||||
| GLU | 0.59 | 0.7 | ||||||
| APLB | 0.08 | 0.12 | ||||||
| ALT | 0.89 | 0.55 | ||||||
| TB | 0.25 | 0.61 | ||||||
| AFP | 0.002 | 1.687(1.028–2.771) | 0.04 | 0.004 | ||||
| ALB | 0.56 | 0.71 | ||||||
| GGT | 0.01 | 0.004 | ||||||
| CHOL | 0.56 | 0.51 | ||||||
| TG | 0.24 | 0.32 | ||||||
| HDL | 0.36 | 0.57 | ||||||
| LDL | 0.01 | 1.868(1.036–3.368) | 0.04 | 0.045 | ||||
| Tumor size | <0.001 | 2.216(1.379–3.561) | 0.001 | <0.001 | 1.974(1.363–2.862) | <0.001 | ||
| Tumor number | 0.08 | 0.09 | ||||||
| Tumor capsule | 0.04 | 0.26 | ||||||
| Vascular invasion | <0.001 | 2.502(1.542–4.061) | <0.001 | <0.001 | 1.997(1.336–2.984) | 0.001 | ||
| Edmondson grade | 0.054 | 0.007 | 1.458(0.98–2.17) | 0.06 | ||||
| TNM stage | 0.003 | 0.001 | ||||||
| ApoA1 | 0.02 | 0.587(0.352–0.979) | 0.04 | 0.01 | 0.607(0.413–0.893) | 0.01 | ||
| ApoB | 0.36 | 0.83 | ||||||
| ApoE | 0.18 | 0.39 | ||||||
Note: Univariate analysis: Kaplan-Meier method; multivariate analysis: Cox proportional hazards regression model.
Abbreviations: BMI, body mass index; GLU, glucose; APLB, prealbumin; ALT, alanine aminotransferase; TB, total bilirubin; AFP, alpha-fetoprotein; ALB, prealbumin; GGT, glutamyl transpeptidase; HbA1C, hemoglobin A1C; CRP, C reactive protein; TC, total cholesterol; TG, triglycerides; HDL, high-density lipoprotein; LDL, low-density lipoprotein; OS, overall survival; DFS, disease free survival; HR, hazard ratio; CI, confidence interval.