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. 2020 Dec 9;11:590459. doi: 10.3389/fimmu.2020.590459

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Copyright © 2020 Ahmed

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment of host genes in cells infected with SARS-CoV-2 and their biological network. (A) GO and KEGG pathways functional enrichment of up-regulated host genes. (B) SARS-CoV-2 induced the Host gene regulatory network (SiHgrn). (C) MCODE clusters extracted from the SiHgrn network. MCODE score is given in the bracket. A red node and a green node represent an up-regulated and down-regulated gene, respectively, in DEHGs, while the blue node represents without expression value. GO, Gene Ontology; BP, Biological Processes; MF, Molecular Function; CC, Cell Component; KEGG, Kyoto Encyclopedia of Genes and Genomes.