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. 2020 Dec 9;11:590459. doi: 10.3389/fimmu.2020.590459

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Copyright © 2020 Ahmed

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment of Cluster 1 and its potential upstream regulators. (A) GO and KEGG pathways functional enrichment. (B) MSigDB Hallmark and positional gene sets enrichment. (C) Potential upstream regulators of Cluster 1 genes. Each column indicates the gene of Cluster 1, while each row indicates TF identified by iRegulone. Up-regulated DEHGs in the cluster are red with positive log2FC. TF binding with the mRNA is in purple, while non-binding in cyan.