Table 4.
The differentially expressed host genes (DEHGsCOVID-19) shows the overlapping with host response pathways using NDEx v2.4.5.
| Pathway Name | Up-regulated gene | Down-regulated gene |
|---|---|---|
| WP530—Cytokines and inflammatory response | No gene | IL1B, IL12B, TNF, IL6 |
| WP4341—Non-genomic actions of 1,25 dihydroxyvitamin D3 | STAT1, STAT2, IFI44L, ISG15, OAS1, OAS2, OAS3, RSAD2, PIK3R1, PIK3C2A |
CAMK2B, VDR, TNF, CYP27B1, CYP24A1, CXCL8, IL6, CAMK2A, PRKCB, RXRA, PRKCA, PIK3C2B, MAPK13 |
| WP4197—The human immune response to tuberculosis | STAT1, STAT2, JAK2, PSMB8, TAP1, IFI35, IFIT1, IFITM1, IFIT3, OAS1, MX1 | No gene |
| WP3617—Photodynamic therapy-induced NF-kB survival signaling | No gene | IL1B, TNF, MMP9, IL6, PTGS2 |
| WP4495—IL-10 anti-inflammatory signaling pathway | STAT1, STAT2 | TNF, IL6, HMOX1 |
| WP619—Type II interferon signaling (IFN-γ) | IFIT2, STAT1, STAT2, JAK2, EIF2AK2, OAS1, HLA-B, GBP1, TAP1 | IL1B |
| WP3624—Lung fibrosis | MT2A and EDN1 | IL1B, CCR3, CXCL8, IL12B, TNF, CYSLTR2, FGF1, IL6, BMP7, MMP9, MUC5B, SFTPC, MECP2, TGFA, HMOX1 |
| IL27-mediated signaling events | JAK2, STAT1, STAT2 | IL1B, IL12B, TNF, IL6 |
| IL23-mediated signaling events | JAK2, PIK3R1, STAT1 | IL1B, IL12B, TNF, IL6 |