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Berberine inhibited PI3K/AKT/mTOR signaling in the DDP-resistant gastric cancer cells with cisplatin treatment. (A,B) Western blot determined phosphor-PI3K, PI3K, phospho-AKT, AKT, phosphor-mTOR or mTOR protein levels in BGC-823/DDP and SGC-7901/DDP cells after treatment with DDP (30 µM), Berberine (30 µM) or DDP (30 µM) + Berberine (30 µM). *p < 0.05 compared to Blank group; # p < 0.05 compared to DDP (30 µM) group; $ p < 0.05 compared to berberine (30 µM) group (n = 3).
