Table 2.
Top 20 differentially expressed mRNA in endometrioid endometrial adenocarcinomas (EEAs) compared to benign gynecological lesions.
| Gene name | Log2 fold change | P-value | Gene.sets |
|---|---|---|---|
| MELK | 3.45 | 7.27E-09 | Cell Proliferation |
| EXO1 | 3.97 | 1.27E-08 | Cell Proliferation, DNA Damage Repair |
| SLC7A5 | 3.2 | 3.73E-08 | Metabolic Stress |
| CCNB1 | 2.4 | 4.46E-08 | Cell Proliferation |
| CXCL8 | 4.85 | 4.77E-08 | Cytokine and Chemokine Signaling, Metabolic Stress |
| IL2RA | 3.72 | 6.18E-08 | Costimulatory Signaling, Cytokine and Chemokine Signaling, JAK-STAT Signaling, PI3K-Akt |
| TYMS | 2.54 | 6.36E-08 | Cell Proliferation |
| CXCL10 | 4.57 | 6.37E-08 | Cytokine and Chemokine Signaling, Lymphoid Compartment |
| CEP55 | 4.03 | 9.46E-08 | Cell Proliferation |
| ANLN | 2.85 | 1.05E-07 | Cell Proliferation |
| MMP9 | 4.9 | 1.19E-07 | Angiogenesis, Immune Cell Adhesion and Migration, Matrix Remodeling and Metastasis |
| IL7R | 2.57 | 1.26E-07 | Cytokine and Chemokine Signaling, JAK-STAT Signaling, PI3K-Akt |
| CXCL9 | 5.5 | 1.53E-07 | Cytokine and Chemokine Signaling, Lymphoid Compartment |
| RRM2 | 2.29 | 1.7E-07 | Cell Proliferation |
| HMGA1 | 3.16 | 1.99E-07 | Epigenetic Regulation, Metabolic Stress |
| FCGR3A/B | 2.39 | 2.62E-07 | |
| MKI67 | 3.47 | 2.81E-07 | Cell Proliferation |
| CXCL1 | 4.91 | 3.35E-07 | Antigen Presentation, Cytokine and Chemokine Signaling, Myeloid Compartment |
| CXCL11 | 5.56 | 3.77E-07 | Cytokine and Chemokine Signaling, Lymphoid Compartment |
| CENPF | 3.15 | 4.11E-07 | Cell Proliferation |