Table 4.
Top 20 differentially expressed mRNAs in endometrial adenocarcinoma with lymph node (LN) metastasis compared to expression in the lymphovascular space involvement (LVSI-LN-) group without metastasis.
| Gene name | Log2 fold change | P-value | Gene sets |
|---|---|---|---|
| COMP | 4.46 | 1.4E-05 | Matrix Remodeling and Metastasis, PI3K-Akt |
| AXIN1 | 0.849 | 1.62E-05 | Wnt Signaling |
| APH1B | -1.23 | 4.54E-05 | Notch Signaling |
| PSMB5 | 0.718 | 0.000213 | Antigen Presentation, Apoptosis, Cell Proliferation, Costimulatory Signaling, Hedgehog Signaling, NF-κB Signaling |
| EIF2AK2 | -0.659 | 0.000496 | Interferon Signaling |
| ATF3 | -2.6 | 0.000498 | Antigen Presentation |
| SLC11A1 | 1.95 | 0.000669 | Myeloid Compartment |
| MELK | 1.31 | 0.000681 | Cell Proliferation |
| EZH2 | 1.13 | 0.000728 | Angiogenesis, Epigenetic Regulation, Metabolic Stress |
| BIRC5 | 1.77 | 0.00073 | Apoptosis, Cell Proliferation |
| CCNE1 | 2.38 | 0.000805 | Angiogenesis, Cell Proliferation, Metabolic Stress, PI3K-Akt |
| ANLN | 1.19 | 0.000912 | Cell Proliferation |
| CENPF | 1.69 | 0.000913 | Cell Proliferation |
| IL1RN | 2.14 | 0.00102 | Cytokine and Chemokine Signaling, Myeloid Compartment |
| TGFB2 | -1.42 | 0.00103 | MAPK, Matrix Remodeling and Metastasis, TGF-β Signaling |
| PRLR | -1.96 | 0.00107 | Cytotoxicity, JAK-STAT Signaling, PI3K-Akt |
| AQP9 | 1.83 | 0.00109 | Metabolic Stress |
| CCL18 | 2.06 | 0.00119 | Cytokine and Chemokine Signaling |
| TRIM21 | -0.564 | 0.00121 | Antigen Presentation, Interferon Signaling |
| FGF13 | -1.36 | 0.00129 | MAPK, PI3K-Akt |
LVSI, lymphovascular space involvement; LN, lymph node.