Table 5.
Top 20 differentially expressed mRNAs in endometrial adenocarcinoma with lymph node (LN) metastasis compared to those in endometrial adenocarcinoma with lymphovascular space involvement (LVSI).
| Gene name | Log2 fold change | P-value | Gene sets |
|---|---|---|---|
| ATF3 | -3.02 | 0.000553 | Antigen Presentation |
| ARNT2 | -0.597 | 0.00147 | _ |
| WNT4 | 1.56 | 0.0019 | Hedgehog Signaling, Wnt Signaling |
| HLA-DOA | -1.15 | 0.00208 | Antigen Presentation, Immune Cell Adhesion and Migration |
| DUSP1 | -2.1 | 0.00244 | MAPK |
| CD69 | -1.52 | 0.00285 | Costimulatory Signaling |
| TAP1 | -1.4 | 0.0034 | Antigen Presentation |
| IL6 | -2.43 | 0.00377 | Cytokine and Chemokine Signaling, Hypoxia, JAK-STAT Signaling, Metabolic Stress, PI3K-Akt |
| STAT1 | -0.954 | 0.00407 | Cytokine and Chemokine Signaling, Cytotoxicity, Interferon Signaling, JAK-STAT Signaling, Lymphoid Compartment |
| TGFB2 | -0.99 | 0.00432 | MAPK, Matrix Remodeling and Metastasis, TGF-β Signaling |
| GBP4 | -1.59 | 0.00436 | Interferon Signaling |
| GBP1 | -1.51 | 0.00455 | Interferon Signaling |
| MX1 | -1.23 | 0.00506 | Cytotoxicity, Interferon Signaling, Lymphoid Compartment |
| HERC6 | -0.99 | 0.00573 | _ |
| PSMB9 | -1.21 | 0.0059 | Antigen Presentation, Apoptosis, Cell Proliferation, Costimulatory Signaling, Hedgehog Signaling, NF-κB Signaling |
| NLRC5 | -0.848 | 0.00619 | _ |
| EGR1 | -1.79 | 0.00678 | Costimulatory Signaling, Interferon Signaling, Lymphoid Compartment |
| TAP2 | -0.737 | 0.00745 | Antigen Presentation |
| SAMSN1 | -0.965 | 0.00866 | _ |
| DTX3L | -0.406 | 0.0087 | Antigen Presentation, Notch Signaling |
LVSI, lymphovascular space involvement; LN, lymph node.