Figure 2.
Comparison of the 10 × g versus 15 × g Hypergravity Transcriptomes
(A) Venn diagrams depicting the degree of overlap between genes differentially up- or downregulated by 10 × g versus 15 × g hypergravity exposure, as based on the rank-rank hypergeometric overlap (RRHO) analysis.
(B) Non-redundant, enriched Gene Ontology Biological Process terms for each possible overlap. Number of genes enriched in a given term are provided within associated boxes of the heatmap. Darker shading denotes greater significance.
(C) Predicted transcription factors of each common-/uniquely regulated gene set.
(D) Quantity (in boxes) and significance (green shading scale) of enriched protein-protein interactions among the genes of each possible overlap, across a range of interaction “confidence” cutoffs.
(E) Hub proteins (and their interactions) for commonly up-/downregulated genes, as well as genes uniquely regulated by 15 × g gravity (relative to 10 × g). Largest node depicts top-ranked hub protein.