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. 2020 Nov 18;11:585655. doi: 10.3389/fimmu.2020.585655

Figure 2.

Figure 2

The conceptual model of immunosenescence and inflammaging mechanism of CSVD. Immunosenescence and inflammaging affect both vascular function and BBB intactness that are keys of CSVD initiation. Cerebral vascular dysfunctions are various that further lead to pathological changes that can be found on neuroimaging and clinical features.