. 2020 Dec 22;324(24):2497–2508. doi: 10.1001/jama.2020.23138

Table 2. Primary Outcome at 6 Months.

36-Item Short Form Health Survey^a	At baseline		At 6 mo
36-Item Short Form Health Survey^a	Digoxin (n = 80)	Bisoprolol (n = 80)	Digoxin (n = 76)	Bisoprolol (n = 74)	Adjusted mean difference (95% CI)^b	P value
Physical component summary score (PCS), mean (SD)^c	28.5 (12.0)	26.7 (10.5)	31.5 (12.0)	29.3 (11.7)	1.3 (−1.2 to 3.9)	.30
PCS normalized for the UK population, mean (SD)^c^,^d	28.9 (11.6)	27.2 (10.2)	31.9 (11.7)	29.7 (11.4)	1.4 (−1.1 to 3.8)	.28

^{^a}

Patient responds to 36 questions reflecting 8 domains of general physical and emotional health.

^{^b}

Compares digoxin with bisoprolol and was adjusted for baseline values (eg, for PCS, 31.5 vs 29.3, respectively, and not the difference in change from baseline). The bisoprolol group is used as the reference group. Higher values indicate better response with digoxin therapy. All adjusted models also include sex, age at randomization, modified European Heart Rhythm Association class, and left ventricular ejection fraction percentage.

^{^c}

Range is from 0 to 100. Higher values indicate better patient-reported quality of life (additional details regarding the scoring process appear in the eMethods in Supplement 3).

^{^d}

Allows for comparison across studies. A score of 50 is the expected normal score (additional details regarding the component domains appear in eFigure 3 in Supplement 3).