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. 2020 Oct 5;18(12):3359–3370. doi: 10.1111/jth.15095

FIGURE 3.

FIGURE 3

Normal heart function in mice with JAK2V617F‐mutant blood cells and wild‐type vascular endothelial cells. A, Experimental scheme to generate a chimeric murine model with JAK2V617F‐mutant blood cells and wild‐type vascular endothelium. B, Blood counts in recipient mice of either Tie2‐cre control (gray) or Tie2FF1 (black) marrow cells 22 weeks after transplantation (n = 5 mice in each group). C, Serial measurements of ejection fraction, fractional shortening, and left ventricular (LV) volumes in recipients of Tie2‐cre control marrow (dotted line) and recipients of Tie2FF1 marrow (black line; n = 5 mice in each group). D, Ly‐6Chi monocytes in recipient mice of Tie2‐Cre control (gray) or Tie2FF1 (black) marrow cells 22 weeks after transplantation (n = 5 mice in each group). E, Representative hematoxylin/eosin staining of intramyocardial coronary arterioles (arrow) in a recipient mouse of Tie2FF1 marrow (magnification 40×). Statistical significance for B–D was determined by the Mann‐Whitney test. *P < .05