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. 2020 Dec 20;16:1744806920970099. doi: 10.1177/1744806920970099

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — IPSE reduces resiniferatoxin-induced, pain-related freezing behaviors in an IL-4- and nuclear localization sequence-dependent manner. (a) Mice were administered intravenous phosphate-buffered saline (PBS) followed by intravesical PBS/Tween/ethanol vehicle (“PBS-Veh”), intravenous PBS with intravesical resiniferatoxin in vehicle (“PBS-RTx”), or one intravenous dose of the H06 H-IPSE ortholog of IPSE 24 hours before intravesical resiniferatoxin in vehicle (“H-IPSE-RTx”). (b) Mice were given intravenous PBS and intravesical PBS (“saline”), intravenous PBS and intravesical PBS/Tween/ethanol vehicle (“Vehicle”), intravenous PBS and intravesical resiniferatoxin in vehicle (“RTx”), recombinant IL-4 given intraperitoneally followed by intravesical resiniferatoxin in vehicle (“IL-4”), the H06 H-IPSE ortholog of IPSE given intravenously 24 hours before intravesical PBS with resiniferatoxin in vehicle (“H-IPSE”), the H06 H-IPSE ortholog of IPSE 24 hours given intravenously and anti-IL-4 antibody given intraperitoneally 30 minutes before resiniferatoxin in vehicle administered intravesically (“H-IPSE+α-IL4”), or a nuclear localization sequence (NLS) mutant of H06 H-IPSE given intravenously 24 hours before resiniferatoxin in vehicle administered intravesically (“H-IPSE^NLS”).