Table 1.
Age at first exposure to FVIII concentrates stratified for FVIII activity and for family history of hemophilia
| Baseline FVIII:C, IU/dL | Age at ED 1, years | |||
|---|---|---|---|---|
|
All patients N = 873 |
Positive FH N = 534 |
Negative FH N = 258 |
||
| Moderate, 2‐5 | N = 292 | 2.5 (1.2‐5.7) | 2.0 (1.0‐5.0) | 3.4 (1.8‐6.6) |
| Moderate, in categories | ||||
| 2 | N = 65 | 1.7 (1.1‐5.0) | 1.4 (0.9‐2.5) | 3.3 (1.4‐6.9) |
| 3‐5 | N = 227 | 2.8 (1.2‐6.0) | 2.4 (1.0‐5.0) | 3.4 (2.0‐6.5) |
| Mild, 5‐40 | N = 581 | 4.4 (1.7‐9.4) | 3.9 (1.4‐7.9) | 6.5 (2.4‐13.0) |
| Mild, in categories | ||||
| 5‐10 | N = 221 | 3.8 (1.4‐7.5) | 3.0 (1.2‐5.7) | 6.4 (2.7‐10.8) |
| 10‐15 | N = 149 | 4.2 (1.7‐9.2) | 3.3 (1.5‐6.6) | 7.2 (1.8‐15.9) |
| 15‐20 | N = 93 | 4.2 (1.7‐8.9) | 4.5 (2.3‐11.0) | 4.2 (1.4‐8.9) |
| 20‐25 | N = 57 | 4.3 (1.9‐11.2) | 3.3 (1.7‐9.2) | 6.1 (2.0‐13.3) |
| 25‐40 | N = 61 | 9.7 (4.8‐16.0) | 8.0 (3.9‐15.2) | 12.1 (6.5‐19.0) |
| Total, 2‐40 | N = 873 | 3.7 (1.4‐7.7) | 3.1 (1.3‐6.5) | 5.2 (2.1‐9.9) |
Values are given in medians and interquartile ranges (IQR).
Abbreviations: ED, exposure day; FH, family history of hemophilia; FVIII, factor VIII.