Table 2.
Median age at first 20 exposures to FVIII concentrates stratified for FVIII activity and for treatment indication
| Baseline FVIII:C, IU/dL | Treatment indication |
Age at ED1 N = 104 |
Age at ED5 N = 95 |
Age at ED10 N = 82 |
Age at ED15 N = 68 |
Age at ED20 N = 52 |
|
|---|---|---|---|---|---|---|---|
| Moderate, 2‐5 | N = 48 | All | 4.5 (1.4‐7.5) | 5.2 (3.2‐9.4) | 5.9 (3.8‐10.7) | 7.6 (3.8‐11.2) | 10.9 (4.9‐14.2) |
| N = 41 | Bleeds | 3.2 (1.4‐7.4) | 4.8 (2.7‐8.7) | 5.1 (2.5‐9.5) | 5.2 (3.3‐10.9) | 9.1 (4.7‐12.3) | |
| Mild, 5‐40 | N = 56 | All | 3.8 (1.3‐8.4) | 5.7 (2.8‐9.1) | 8.6 (4.4‐11.7) | 9.0 (5.8‐12.8) | 9.6 (6.7‐14.3) |
| N = 48 | Bleeds | 4.0 (2.2‐8.8) | 7.7 (3.9‐12.5) | 9.6 (5.8‐14.6) | 10.3 (7.3‐14.2) | 10.8 (8.5‐15.5) | |
| Total, 2‐40 | N = 104 | All | 4.0 (1.4‐7.6) | 5.6 (2.9‐9.3) | 7.5 (4.4‐11.3) | 8.9 (4.9‐12.1) | 10.2 (6.5‐14.2) |
| N = 89 | Bleeds | 3.9 (1.5‐7.6) | 5.8 (3.5‐11.0) | 7.6 (4.3‐12.0) | 9.0 (4.9‐13.0) | 10.2 (7.1‐13.0) | |
Values are given in medians (interquartile ranges).
Abbreviation: ED, exposure day; FVIII, factor VIII.