Figure 6.

Time‐to‐event modeling of peripheral neuropathy—platform modeling. ⁴¹ (A) Model structure. The hazard in the time‐to‐event model is driven by individually predicted antibody‐drug conjugate plasma concentrations (Cp). Transit and effect compartments were included to account for the slow initial event rate. The hazard was linearly related to the concentration in the effect compartment (Ce). In addition, a Weibull function on top of the drug effect on hazard was added for slight improvement over time. Covariates in the full and final models were included assuming proportional hazards (Prop HZ). (B) Estimated hazard ratios (95%CI) for covariate effects based on full and final model. ALBU, albumin; BWT, body weight; CI, confidence interval; Ctransit, concentration in the transit compartment; ECOG, Eastern Cooperative Oncology Group; Ktr, first‐order transit rate; PN, peripheral neuropathy.