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Mechanism of transamination. For clarity, the individual steps of aldimine/ketimine formation and hydrolysis as well as transimination are not shown. The mechanism is symmetric – referred to as a “ping‐pong” bi‐bi or shuttle mechanism – and fully reversible. Note: the ketimine intermediates are a second aldimine if one of the R‐groups is a hydrogen. Catalytic lysine: red; amine donor: blue; ketone acceptor: green.
