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. 2020 Oct 1;12(24):6082–6102. doi: 10.1002/cctc.202001107

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© 2020 The Authors. Published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Scheme 1 — Synthesis of L‐ephedrine: Benzoin‐type addition of acetaldehyde (formed in‐situ by yeast metabolism) to benzaldehyde (now known to be catalyzed by pyruvate decarboxylase), ^[14] followed by reductive amination with methylamine. ^[11]