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. 2020 Oct 1;12(24):6082–6102. doi: 10.1002/cctc.202001107

Scheme 2.

Scheme 2

Top: Isomerization of d‐glucose to d‐fructose, catalyzed by an immobilized glucose isomerase as used in the production of HFCS. Bottom: Hydrolysis of Penicillin to give 6‐APA, which can then be acylated to give several semi‐synthetic antibiotics.