Skip to main content
. 2020 Oct 1;12(24):6082–6102. doi: 10.1002/cctc.202001107

Scheme 5.

Scheme 5

Competing acyl transfer (red) and hydrolysis reactions (blue) catalyzed by Penicillin acylase. By tuning the characteristics of the support, synthesis can be kinetically favored over the thermodynamically favored hydrolysis reaction.