Scheme 6.

Three examples of enzymatic cascades. A) Transformation of amines into alcohols, using an immobilized transaminase and either an ADH or KRED in flow. ^[142] B) A Suzuki cross‐coupling to produce a bi‐aryl ketone which is then aminated using a transaminase catalyst. The transaminase had to tolerate 30 % DMF carried over from the cross‐coupling, as well Pd catalyst, excess base, and unreacted boronic acid. ^[143] C) halogenation of aromatic compounds using a halogenase, followed by a Suzuki coupling. The enzyme had to be separated, either by ultrafiltration, immobilization, or compartmentalization from the Pd catalyst. ^[144]