Table 2.
ROI total area (mm2) and area proportions of positive cells (%) in periodontitis (n = 40) and peri‐implantitis (n = 40) sites
| ROI | Lesion | Total area (mm2) | Positive area (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| γ‐H2AX | 8‐OHdG | Chk2 | MPO | CD68 | iNOS | NOX2 | MPO/PAD4 | |||
| ICT | Periodontitis | 2.44 ± 0.31 | 3.01 ± 2.78 | 3.09 ± 3.89 | 15.10 ± 9.76 | 3.21 ± 3.03 | 1.32 ± 1.71 | 4.95 ± 4.32 | 5.56 ± 4.98 | 0.14 ± 0.31 |
| Peri‐implantitis | 4.23 ± 0.19* | 3.37 ± 2.39 | 1.81 ± 3.04 | 15.81 ± 12.49 | 8.95 ± 8.56* | 5.12 ± 2.77* | 7.56 ± 5.32* | 7.02 ± 7.80 | 0.17 ± 0.25 | |
| PE | Periodontitis | 0.64 ± 0.20 | 3.79 ± 5.19 | 4.235 ± 4.99 | 16.97 ± 11.65 | 4.42 ± 4.89 | 0.59 ± 0.93 | 7.33 ± 7.41 | 2.97 ± 3.53 | 0.20 ± 0.33 |
| Peri‐implantitis | 0.77 ± 0.20* | 5.28 ± 6.17 | 2.92 ± 5.86* | 18.20 ± 15.21 | 7.06 ± 6.86 | 0.64 ± 0.96 | 8.89 ± 7.30 | 4.95 ± 6.43 | 0.45 ± 0.76 | |
| NCT | Periodontitis | 0.40 ± 0.04 | 0.27 ± 0.28 | 0.43 ± 0.46 | 3.63 ± 3.31 | 0.35 ± 1.31 | 0.17 ± 0.18 | 0.74 ± 9.63 | 0.10 ± 0.16 | 0.00 ± 0.01 |
| Peri‐implantitis | 0.35 ± 0.04 | 0.59 ± 0.44* | 0.42 ± 0.77 | 4.10 ± 4.67 | 0.42 ± 0.91* | 0.29 ± 0.30 | 1.19 ± 0.90* | 0.63 ± 1.76* | 0.01 ± 0.02* | |
Values in mean ± SD.
Abbreviations: ICT, infiltrated connective tissue; PE, pocket epithelium; NCT, non‐infiltrated connective tissue; γ‐H2AX, phosphorylated histone family member X; 8‐OHdG, 8 hydroxyguanosine; Chk2, checkpoint kinase 2; MPO, myeloperoxidase; iNOS, inducible nitric oxide synthase; NOX2, NADPH oxidase 2; PAD4, peptidylarginine deiminase 4.
*
p < 0.05 (Mann–Whitney U test).