Figure 8.

A) Imino proton spectral region of Myc‐dup5 (0.5 mm) titrated with PIQ at 20 °C. B) 1D and ROESY spectrum showing the G4 imino proton spectral region of Myc‐dup5 in the presence of 0.6 equivalent of PIQ at 20 °C. Exchange crosspeaks connect guanine imino resonances of free and complexed species. Imino proton resonances are assigned to G residues in free Myc‐dup5 and in the ligand‐hybrid complex by black and red numbers, respectively. C) Imino chemical shift differences of G4 residues between complexed (with 0.6 equiv. of PIQ) and free Myc‐dup5. Imino resonances of G19 and G27 could not be unambiguously assigned.