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. 2020 Sep 14;41(1):223–245. doi: 10.1002/med.21730

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© 2020 The Authors. Medicinal Research Reviews Published by Wiley Periodicals LLC

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Schematic representation of basic domain organization of human BET (bromodomain and extra‐terminal domain) family proteins; BRD2, BRD3, BRD4, and BRDT. BET proteins contain two ~110 amino acid bromodomains (BD1 and BD2) and an extra‐terminal domain (ET). Only BRD4 and BRDT have a C‐terminal motif (CTM) [Color figure can be viewed at wileyonlinelibrary.com]