Figure 1.

Lignan biosynthetic pathway in Sesamum indicum.

Identified enzymes are indicated in black boxes. A dashed arrow indicates the possible route catalysed by putative dirigent protein (DIR) and oxide (Ox.). SiCYP92B14 is a pivotal enzyme that allocates the substrate (+)‐sesamin to (+)‐sesamolin and (+)‐sesaminol through three separate paths via either direct oxidation (path a) or oxidative rearrangement of α‐oxy‐substituted aryl groups (ORA; paths b and c). I, II and III; intermediate compounds. Atom labels ‘X’ represent either hydrogen ‘H’ or chemically introduced deuterium ‘D’ as identified in Murata et al. (2017).