TABLE 2.
Characteristics of Mental Health Between the Different CIPN Groups
| No CIPN (n = 16) | Possible CIPN (n = 6) | Probable CIPN (n = 15) | Confirmed CIPN (n = 26) | P value | ||
|---|---|---|---|---|---|---|
| Treatment | ||||||
| Docetaxel, No. (%) | 11 (39.3) | 4 (14.3) | 9 (32.1) | 4 (14.3) | ||
| Oxaliplatin, No. (%) | 5 (14.3) | 2 (5.7) | 6 (17.1) | 22 (62.9) | .23 | |
| PROMIS depression, T‐score, mean (SD) | 47.5 (11.1) | 44.5 (7.9) | 45.4 (8.5) | 46.7 (9.1) | .38 | |
| docetaxel, T‐score, mean (SD) | 48.2 (11.8) | 45.8 (9.5) | 48.7 (9.1) | 58.0 (11.4) | .22 | |
| oxaliplatin, T‐score, mean (SD) | 46.1 (10.6) | 41.8 (4.8) | 40.4 (4.9) | 44.6 (7.1) | .63 | |
| Symptoms of depression, mild–severe, No. (%) | 5 (31.2) | 1 (16.7) | 3 (20.0) | 3 (11.5) | ||
| PROMIS anxiety, T‐score, mean (SD) | 48.4 (11.6) | 43.6 (8.2) | 49.4 (6.9) | 48.3 (8.9) | .76 | |
| docetaxel, T‐score, mean (SD) | 48.4 (11.6) | 45.9 (9.6) | 48.4 (7.6) | 55.0 (11.4) | .51 | |
| oxaliplatin, T‐score, mean (SD) | 48.3 (12.9) | 39.1 (0.0) | 50.9 (5.8) | 47.0 (8.1) | .84 | |
| Symptoms of anxiety, mild–severe, No. (%) | 4 (25.0) | 1 (16.7) | 2 (13.3) | 5 (19.2) | ||
| PROMIS sleep, T‐score, mean (SD) | 50.1 (6.4) | 44.8 (12.3) | 51.4 (5.0) | 48.4 (7.3) | .65 | |
| docetaxel, T‐score, mean (SD) | 51.2 (6.8) | 44.9 (11.9) | 52.5 (4.8) | 51.7 (8.2) | .57 | |
| oxaliplatin, T‐score, mean (SD) | 47.6 (4.8) | 44.5 (18.1) | 49.8 (5.1) | 47.8 (7.1) | .80 | |
| Sleep impairment, mild–severe, No. (%) | 4 (25.0) | 2 (33.3) | 3 (20.0) | 7 (26.9) | ||
| PROMIS fatigue, T‐score, mean (SD) | 48.5 (9.3) | 47.0 (9.7) | 52.4 (8.3) | 48.0 (9.1) | .18 | |
| docetaxel, T‐score, mean (SD) | 50.8 (8.3) | 48.0 (11.4) | 52.2 (6.2) | 57.2 (13.7) | .22 | |
| oxaliplatin, T‐score, mean (SD) | 43.6 (10.4) | 45.0 (8.3) | 52.8 (11.5) | 46.4 (7.3) | .58 | |
| Symptoms of fatigue, mild–severe, No. (%) | 6 (37.5) | 2 (33.3) | 8 (53.3) | 9 (34.6) | ||
| Quality of life EQ5D VAS, median (IQR) | 80.0 (79.2; 90.0) | 89.0 (85.0; 94.0) | 77.0 (60.0; 85.0) | 87.0 (69.0; 90.0) | .18 | |
| docetaxel, median (IQR) | 80.0 (79.0; 90.0) | 85.0 (85.0; 89.0) | 79.0 (62.5; 82.5) | 68.0 (38.5; 89.2) | .22 | |
| oxaliplatin, median (IQR) | 80.0 (77.5; 97.5) | 94.0 (86.5; 99.0) | 73.0 (54.5; 90.0) | 88.0 (69.0; 90.0) | .58 | |
| Confirmed CIPN without pain(n = 15) | Confirmed CIPN with pain(n = 11) | P value | ||||
|---|---|---|---|---|---|---|
| Treatment | ||||||
| Docetaxel, No. (%) | 1 | 3 | ||||
| Oxaliplatin, No. (%) | 14 | 8 | .055 | |||
| PROMIS depression, T‐score, mean (SD) | 44.4 (7.3) | 49.8 (10.6) | .44 | |||
| Symptoms of depression, mild–severe, No. (%) | 1 (6.7) | 2 (18.2) | ||||
| PROMIS anxiety, T‐score, mean (SD) | 45.9 (7.8) | 51.4 (9.6) | .35 | |||
| Symptoms of anxiety, mild–severe, No. (%) | 1 (6.7) | 4 (36.4) | ||||
| PROMIS sleep, T‐score, mean (SD) | 46.0 (6.3) | 51.6 (7.4) | .16 | |||
| Sleep impairment, mild–severe, No. (%) | 3 (20.0) | 4 (36.4) | ||||
| PROMIS fatigue, T‐score, mean (SD) | 43.7 (6.9) | 53.9 (8.6) | .002 | |||
| Symptoms of fatigue, mild–severe, No. (%) | 2 (13.3) | 4 (63.6) | ||||
| Quality of life EQ5DVAS, median (IQR) | 90.0 (80.0; 90.0) | 69.0 (49.0; 87.0) | .005 | |||
Note: P value adjusted for age, gender, and if relevant type of chemotherapy.
Abbreviations: PROMIS, Patient‐Reported Outcome Measurement Information System; IQR, interquartile range.