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A. Inhibition of HDAC 1, 2, 3, 6, and 8 by the hit compound 3 n and compound 3 o. *Vorinostat was used as control compound except in the case of HDAC8, where panobinostat was used. n≥2, each in duplicate wells. B. Docking poses of 3 n and 3 o in the human HDAC6 (PDB: 5EDU). Both compounds were individually docked to human HDAC6 using RosettaLigand in iterative rounds of focused docking.
