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. 2020 Oct 9;59(50):22494–22499. doi: 10.1002/anie.202006725

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© 2020 The Authors. Published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A. Synthesized proof of concept HDAC degrader 4 and inhibitory activities against HDAC1, 2, 3, 6, and 8. B. HPLC‐chromatogram of the test cleavage of crude proof of concept PROTAC 4 (cleavage mix: 5 % TFA in CH₂Cl₂, 1 h, r.t.). C. Immunoblot analysis of cell lysate after HL‐60 cells were treated with 4 at various concentrations (0.1 μM, 1 μM and 10 μM).