Scheme 1.

Solid‐phase supported strategy for the parallel synthesis of DNA‐alkylating HDACi hybrid molecules. a.) PhthN‐OH (3.5 equiv), Et₃N (3.5 equiv), DMF, r.t., 48 h. b.) 5 % N₂H₄⋅H₂O in MeOH, r.t., 2× 15 min. c.) Fmoc‐NH‐Linker‐COOH (2.0 equiv), HATU (2.0 equiv), HOBt⋅H₂O (2.0 equiv), DIPEA (3.0 equiv), DMF, r.t., 20 h. d.) 20 % piperidine in DMF, 2x 5 min. e.) Cap‐COOH (3.0 equiv), HATU (3.0 equiv), DIPEA (5.0 equiv), DMF, r.t., 20 h, dark environment. f.) 5 % TFA in CH₂Cl₂, r.t.,1 h.