Table 1.
Loadings of synthesized HAIRs and stability after >6 months stored at 4 °C monitored by repetition of the loading and crude purity determination.
|
Entry |
preloaded resin |
Loading[a] (mmol g−1) |
Loading[a] >6 months (mmol g−1) |
Crude purity[b] >6 months |
|---|---|---|---|---|
|
HAIR A |
|
0.90 |
0.91 |
96 % |
|
HAIR B |
|
0.96 |
0.97 |
95 % |
|
HAIR C |
|
0.87 |
0.90 |
96 % |
|
HAIR D |
|
0.81 |
0.83 |
96 % |
|
HAIR E |
|
0.87 |
0.85 |
95 % |
[a] Loadings were photometrically determined at 300 nm after deprotection of the Fmoc‐group using 20 % piperidine in DMF. [b] Crude purities were analyzed by HPLC after test cleavage with 5 % TFA in dichloromethane for 1 h.