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. 2020 Oct 27;38(12):1578–1593. doi: 10.1002/stem.3287

FIGURE 6.

FIGURE 6

FBLN5 restores the myelination defects in the CMT zebrafish model. A, Lateral view images of the Tg(claudin K:gal4‐vp16;uas:egfp) control and zebrafish injected with pmp22 mRNAs alone or with fbln5 mRNAs at 5 dpf. The images within the rectangles are magnified in the bottom panels. SCT, spinal cord tracts; PLLn, posterior lateral line; A, anterior; P, posterior; OE, overexpression. Scale bars, 100 μm. B, Quantification of the relative intensities of PLLn in equivalent fields of view in the images of (A). Statistical significance was determined using the one‐way ANOVA followed by Dunnett's post hoc test (***P < .001). C, TEM images of cross‐sectioned zebrafish of the indicated genotype at 5 dpf. The images within the rectangles are magnified in the bottom panels. The red lines indicate the thicknesses of the myelin sheaths in the Mauthner axons. A, axon. Scale bars, 2 μm. D, Quantification of the G‐ratios calculated in mauthner axons of the indicated zebrafish. Statistical significance was determined using the one‐way ANOVA followed by Dunnett's post hoc test (*P < .05). The data are shown as the mean ± SD (B, D)