Table 10.
Aging‐associated diseases and genes involved in pathogenesis and progression, up‐ or downregulated by adaptogens tested in isolated neuroglia cells
| Cancer and gastrointestinal | Adenocarcinoma, prostate carcinoma, colon and colorectal cancer, cancer, gastrointestinal tumor, gastric mucosa atrophy | 132 genes |
|---|---|---|
| Organismal injury and abnormalities | Physical disability | PDE11A, PDE3A, PDE4Dupregulated |
| Degeneration of retinal cone cells—inhibition | AIPL1downregulated, CNGB3upregulated | |
| Atrophy of gastric mucosa | CCKBRdownregulated | |
| Hypoestrogenism | ESR1downregulated | |
| Postmenopausal vulvar atrophy | ESR1б MTNR1Adownregulated | |
| Pain—inhibition | KCNK10, PDE11A, PDE3A, PDE4D, SCN2Bupregulated | |
| Cone dystrophy | CDHR1, ESR1downregulated | |
| Pelvic organ prolapses | CNGB3, SERPINA1upregulated | |
| Dermatological | Rosacea | AKR1D1upregulated, MMP8downregulated |
| Inflammatory and pulmonary | Pulmonary emphysema‐ inhibition | PDE11A, PDE3A, PDE4D, SERPINA1upregulated |
| Bronchiectasis | PDE11A, PDE3A, PDE4Dupregulated | |
| Chronic bronchitis | MMP8, MTNR1Adownregulated | |
| Neurological and psychological | Non‐24‐h sleep‐wake disorder | MTNR1Adownregulated |
| Sleep‐wake schedule disorder | PDE3Aupregulated | |
| Urological | Recurrent urinary tract infection | ESR1downregulated |
| Cardiovascular | Ischemic cardiomyopathy | PDE11A, PDE3A, PDE4D, PPP1R1Aupregulated |
| Cholesteryl ester transfer protein deficiency | CETPdownregulated | |
| Angina pectoris | PDE11A, PDE3A, PDE4Dupregulated | |
| Cerebral small vessel disease | PDE3Aunregulated | |
| Skeletal and connective tissue | Osteochondrodysplasia | COL9A1downregulated, PDE4Dupregulated |
| Metabolic | Estrogen resistance | ESR1downregulated |