Table 3.
Presentation of Patients Requiring LT Compared With Patients Not Needing an LT Within 12 Months
| LT (n = 7) | No LT (n = 74) | Sensitivity, % | Specificity, % | PPV, % | Youden’s Index | |
|---|---|---|---|---|---|---|
| Diagnosis | ||||||
| Cirrhosis | 5/7 (71) | 26/74 (35) | 71 | 66 | 16 | 0.37 |
| Decompensated cirrhosis | 5/7 (71) | 6/74 (8) | 71 | 92 | 45 | 0.63 |
| Encephalopathy | 4/7 (57) | 1/74 (1) | 57 | 99 | 80 | 0.56 |
| Ascites | 3/7 (43) | 6/74 (8) | 43 | 92 | 33 | 0.35 |
| SBP | 2/7 (29) | 2/74 (3) | 29 | 97 | 50 | 0.26 |
| INR ≥1.5 | 6/7 (86) | 7/63 (11)* | 86 | 89 | 46 | 0.75 |
| MELD score >15 at diagnosis | 7/7 (100) | 21/64 (33) | 100 | 67 | 25 | 0.67 |
| Histology | ||||||
| HAI >12 | 2/3 (66) † | 8/16 (50) † | 66 | 50 | 20 | 0.16 |
| Centrilobular necrosis | 2/3 (66) † | 10/16 (63) † | 66 | 37 | 17 | 0.03 |
| 2 weeks | ||||||
| Increase of bilirubin | 4/5 (80) ‡ | 2/26 (8)§ | 80 | 92 | 67 | 0.72 |
| Decrease of albumin | 1/4 (25) ‡ | 8/27 (30) ‡ | 25 | 70 | 3 | −0.05 |
| Increase of INR | 4/5 (80) * , ‡ | 1/26 (4) * , ‡ | 80 | 96 | 80 | 0.76 |
| Increase of bilirubin or INR | 5/5 (100) * , ‡ | 3/20 (15) * , ‡ , § | 100 | 85 | 63 | 0.85 |
| Decrease MELD >2 points | 3/4 (75) ‡ | 13/26 (50) ‡ | 75 | 50 | 19 | 0.25 |
Data are given as n (%) unless otherwise noted.
*
Patients using oral anticoagulants were excluded from this analysis.
†
Only liver biopsies of acute and AS‐AIH patients were scored.
‡
Laboratory values were not measured at 2 weeks in the remaining patients.
§
11 patients with normal bilirubin at diagnosis were excluded.