FIGURE 3.

Epigenetically “active” gene loci associated with γδ T cell effector functions. CD27⁻and CD27⁺γδ T cells, corresponding to IL‐17⁺and IFNγ⁺γδ T cell subsets, respectively, display active dimethylated H3K4me2 marks in loci of genes associated with their effector functions (from the Chip‐Seq analysis in84). Loci of genes associated with IL‐17 production (blue) are only actively marked in CD27⁻T cells, whereas loci of genes related with IFNγ production (red) are actively marked in both subsets, highlighting the potential of IL‐17⁺γδ T cells to engage in both cytokine programs