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. 2020 Dec 16;4(2):e202000882. doi: 10.26508/lsa.202000882

Figure 6. Integration of multiomic data reveals increased HSF1 dependence in a biosynthetically active subset of acute myeloid leukemia (AML).

Figure 6.

(A) The HSF1 coessentiality network, comprising positive connections to rank 30 and 5 potential secondary nodes per gene, is enriched for genes involved in the heat shock cytosolic proteostasis response. P-value from hypergeometric test. (B) Creation of mRNA, protein, and metabolite signatures of HSF1-dependence (lines with >75th percentile essentiality versus <25th percentile essentiality) across cancer subsets containing at least 10 cell lines. Enrichment P-values (hypergeometric overlap test) for the most enriched signatures in each subset are shown. (C) Integration of cancer cell line encyclopedia multiomic data to characterize AML cell l`ines stratified by HSF1 dependence (upper versus lower quartile) reveals that HSF1 is most essential in a biosynthetically active subset of AML cell lines. (D) The mRNA signature of translation and HSF1-dependence in AML stratifies AML patients into distinct prognostic groups. P-value from Cox proportional hazards test.