Table 1.

Key expression differences in the central platelet signalling cascade

gene symbol/full name	cascade position*	experimental data
higher abundant in human
TLN1 Talin 1	central, increased in human	[15, 18–28]
CALM3 Calmodulin 3	2nd neighbour*, increased in human	[15, 18, 21–23, 26, 27]
PRKCB Protkinase Ca	2nd neighbour, strong increase in human	[15, 18–25, 27]
APP amyloid ßA4b	2nd neighbour, clearly increase in human	[15, 18–25]
SOD2 SuperoxidDisc	2nd neighbour, clearly increase in human	[15, 18–21, 23–25, 27]
TIMP1 Protease inhibd	2nd neighbour, clearly only human, T	[15, 18, 20–22, 24]
Only Human
PLCB2 Phospholipase Ce	central, only human, good expressed)	[15, 18–22, 24]
MMP9 Metalloproteasef	1st degree*, only human, low expressed	[15, 20]
BDNF brain derived factorg	2nd degree*,	[15, 18, 20, 22]
ITPR3 triphosphat receptorh	central, low expression	[15, 18]
SLC25A6 Solute carrieri	3rd degree*, low expressed	[15, 18, 20–24]
higher abundant in mouse
RASGRP2 Guanyl releasej	1st neighbour	[15, 18–27]
ITGB2 Integrin Beta 2	1st neighbour, good difference,	[15, 20, 25–27]
MYL9 myosin regulationk	2nd neighbour, high expression/ difference	[15, 18, 20–27]
EIF4EBP1 initiation factorl	1st neighbour, very clear difference	[15, 20, 25, 26]
ADAM17 metallopeptidasem	3rd neighbour, clear difference	[15, 18, 19, 25, 26]
ARRB2 Arrestin ß2	1st neighbour, good difference	[15, 18, 20, 25, 26]
CD9 Complementn	2nd neighbour, good marker, higher in mouse	[15, 18, 20–25, 27]
SOD1 SuperoxidDisc	2nd neighbour, high abundant in both	[15, 18–21, 24–27]
ZYX Zyxin protein	1st neighbour, high expression in both	[15, 18–28]
Only Mouse
GNG12 Guanin bindingo	2nd degree, high expression, clear difference	[15, 25–27]
PRKCE protein kinase Cε	2nd degree, high expression, clear difference	[15, 25, 26]
ADCY9 Adenylate Cyclase 9	2nd degree, high expression, clear difference	[15, 25, 26]
Divergent expression levels comparing RNA versus protein
Glycoprotein VIb (only form present in platelets)
For GP6b (glycoprotein VIb (platelet) the mRNA level tends to be increased in mice, but the protein level shows clearly higher abundance in human (mouse higher in transcriptome whereas human higher in proteome)
SRC / Src protein kinase shows different mRNA and protein level regulation in man and mouse (human higher in transcriptome whereas mouse higher in proteome); the higher proteome expression has a clear effect on the switching behaviour of SRC as bistability switch (13)

*Neighbor definition: see methods overview; 2nd degree = 2nd degree neighbor; 3rd degree = 3rd degree neighbor

Abbreviations: ^aProtkinase C Protein kinase C, isoform B, ^bamyloid ßA4 amyloid beta A4 percursor protein, ^cSuperoxidDis superoxide dismutase, ^d Protease inhib TiM metallopeptidase inhibitor 1, ^ePhospholipase C Phospholipase C, isoform B2, ^fMetalloprotease Matrixmetalloprotease 9, ^gBDNF Brain derived neurotrophic factor, ^hITPR3 inositol 1,4,5 triphosphat receptor type 3, ⁱSLC25A6 Solute carrier family 25 (mitochondrial) member 6, ^jRASGRP2 RAS-Guanyl releasing protein 2, ^kmyosin regulation myosin light polypeptide 9, ^lEIF4EBP1 eukaryotic translation initiation factor 4E binding protein1, ^mmetallopeptidase ADAM metallopeptidase domain 17, ⁿCD9 antigen Complement defining protein 9, ^oGuanin binding Guanin nucleotide binding protein gamma 12