Fig. 2.

Ki67 expression in HNSCC cells grown in 3D ± CAFs after treatment with cisplatin and cetuximab. Proliferation in response to treatment with cetuximab and cisplatin was measured by immunohistochemical staining with the proliferation marker Ki67. Quantification of Ki67-positive cells in 5 days old tumor spheroids; data are depicted as Ki67 positive cells/area ± SD, 2 experiments, images = n ≥ 6. *p < 0.05 according to one-way ANOVA with Bonferroni adjustment