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. 2020 Dec 3;11:578346. doi: 10.3389/fphar.2020.578346

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Copyright © 2020 Houriet, Allard, Queiroz, Marcourt, Gaudry, Vallin, Li, Lin, Wang, Kuchta and Wolfender

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multi-component signatures extracted from the FBMN (Figures 3B, 6) and represented in the form of bar chromatograms presenting the feature height intensity as a function of retention time in PI: (A) metabolite profile of the formula showing all formally identified components, (B) bar chromatograms showing seven multi-component signatures. (C) multicomponent signatures for S. glabra and its marker astilbin (SM1), I. tinctoria and isovitexin (I1), P. cuspidatum and E-piceid (PO1), A. sinensis and ligustilide (A1), G. uralensis and uralsaponin A (G1), S. flavescens and oxymatrine (SO1) and S. baicalensis and baicalin (SC1). All X axes represent time dimension, all Y axes feature height intensity. See Supplementary Tables S2–S11 for annotations.