Table 1.
Patient characteristics in different historic transplantation cohorts
| Variable | 1980-1989 | 1990-1999 | 2000-2009 | 2010-2016 |
|---|---|---|---|---|
| Donor cell source | ||||
| Bone marrow | 1479 (99.9) | 3494 (75.1) | 2 913 (19.8) | 2 180 (12.1) |
| Peripheral blood | 1 (0.1) | 1157 (24.9) | 11 784 (80.2) | 15 792 (87.9) |
| Diagnosis | ||||
| Acute lymphoblastic leukemia | 524 (35.4) | 1263 (27.2) | 2 573 (17.5) | 3 056 (17) |
| Acute myeloid leukemia | 770 (52) | 2268 (48.8) | 7 546 (51.3) | 8 953 (49.8) |
| Lymphoma | 83 (5.6) | 550 (11.8) | 2 643 (18) | 2 890 (16.1) |
| Myelodysplastic/myeloproliferative disease | 103 (7) | 570 (12.3) | 1 935 (13.2) | 3 073 (17.1) |
| Complete remission at transplant | ||||
| Yes | 1170 (79.1) | 3050 (65.6) | 9 641 (65.6) | 12 130 (67.5) |
| No | 310 (20.9) | 1601 (34.4) | 5 056 (34.4) | 5 842 (32.5) |
| Age, median (min-max) [IQR], y | 29.2 (18-55.7) [23.1-36] | 37.4 (18-74.7) [28.8-45.2] | 45.7 (18-76.4) [34.4-54.9] | 49.5 (18-83.8) [36.9-58.3] |
| Sex | ||||
| Male | 839 (56.7) | 2667 (57.3) | 8 362 (56.9) | 10 458 (58.2) |
| Female | 641 (43.3) | 1984 (42.7) | 6 335 (43.1) | 7 514 (41.8) |
| Intensity of conditioning | ||||
| Reduced | 0 (0) | 305 (6.6) | 5 667 (38.6) | 7 739 (43.1) |
| Myeloablative | 1480 (100) | 4346 (93.4) | 9 030 (61.4) | 10 233 (56.9) |
| Conditioning contains total body irradiation | ||||
| Yes | 1408 (95.1) | 3348 (72) | 5 827 (39.6) | 4 448 (24.7) |
| No | 72 (4.9) | 1303 (28) | 8 870 (60.4) | 13 524 (75.3) |
| In vivo T-cell depletion | ||||
| Yes | 28 (1.9) | 387 (8.3) | 3 171 (21.6) | 6 052 (33.7) |
| No | 1452 (98.1) | 4264 (91.7) | 11 526 (78.4) | 11 920 (66.3) |
Data are absolute number of patients (percentage), unless noted otherwise.