Table 3.
Description of univariate outcomes in the historic transplantation cohorts
| Outcome | Time | 1980-1989 | 1990-1999 | 2000-2009 | 2010-2016 |
|---|---|---|---|---|---|
| NRM | At 6 mo | 25.1 (22.9-27.3) | 19.9 (18.8-21.1) | 10.8 (10.3-11.3) | 8.4 (8-8.9) |
| At 12 mo | 29.7 (27.4-32) | 24.4 (23.2-25.6) | 14.8 (14.3-15.4) | 12.2 (11.7-12.7) | |
| At 24 mo | 31.5 (29.2-33.9) | 26.7 (25.4-28) | 17.4 (16.8-18) | 14.8 (14.3-15.4) | |
| Overall survival | At 6 mo | 67.4 (65.1-69.8) | 70.6 (69.3-72) | 79.7 (79.1-80.4) | 83.4 (82.8-83.9) |
| At 12 mo | 54.8 (52.3-57.4) | 57.6 (56.2-59) | 67.5 (66.7-68.3) | 72.1 (71.4-72.8) | |
| At 24 mo | 46.1 (43.6-48.7) | 48.3 (46.8-49.7) | 57.3 (56.5-58.1) | 61.9 (61.1-62.7) | |
| Progression-free survival | At 6 mo | 60.2 (57.7-62.7) | 62.3 (60.9-63.7) | 69.2 (68.5-70) | 72.1 (71.4-72.8) |
| At 12 mo | 49.2 (46.7-51.8) | 49.8 (48.3-51.2) | 56.4 (55.6-57.2) | 60.8 (60.1-61.6) | |
| At 24 mo | 42.4 (39.9-45) | 42.3 (40.9-43.8) | 48.2 (47.3-49) | 52.4 (51.6-53.2) | |
| Relapse incidence | At 6 mo | 14.7 (13-16.6) | 17.8 (16.7-18.9) | 20 (19.3-20.6) | 19.5 (18.9-20.1) |
| At 12 mo | 21.1 (19.1-23.2) | 25.8 (24.6-27.1) | 28.8 (28-29.5) | 27 (26.3-27.7) | |
| At 24 mo | 26.1 (23.9-28.4) | 31 (29.7-32.3) | 34.5 (33.7-35.2) | 32.8 (32-33.5) | |
| Acute GVHD grade 2-4 | At 30 d | 27.5 (25.2-29.8) | 28.1 (26.8-29.4) | 16.6 (16-17.3) | 6.2 (5.8-6.6) |
| At 100 d | 36.4 (33.9-38.8) | 37.5 (36.1-38.9) | 27.5 (26.7-28.2) | 24.8 (24.2-25.5) | |
| At 180 d | 36.6 (34.1-39) | 37.8 (36.4-39.3) | 27.8 (27.1-28.6) | 25.4 (24.8-26.1) | |
| Acute GVHD grade 3-4 | At 30 d | 11.5 (9.9-13.2) | 11.4 (10.5-12.3) | 4.7 (4.3-5) | 2.3 (2.1-2.6) |
| At 100 d | 14.5 (12.8-16.4) | 15.6 (14.5-16.7) | 10.8 (10.2-11.3) | 9.7 (9.2-10.1) | |
| At 180 d | 14.7 (12.9-16.5) | 15.7 (14.7-16.8) | 10.9 (10.4-11.4) | 9.9 (9.5-10.4) | |
| Chronic GVHD | At 6 mo | 18.1 (16.1-20.2) | 18.7 (17.5-19.9) | 21.2 (20.5-21.9) | 19.7 (19.1-20.3) |
| At 12 mo | 22.5 (20.3-24.8) | 26.3 (24.9-27.6) | 34.1 (33.3-34.9) | 32.5 (31.7-33.2) | |
| At 24 mo | 24.7 (22.4-27) | 29.2 (27.8-30.6) | 39 (38.1-39.8) | 38.1 (37.3-38.9) | |
| Extensive chronic GVHD | At 6 mo | 7.6 (6.2-9.1) | 8.3 (7.5-9.2) | 10.4 (9.8-10.9) | 8.3 (7.8-8.7) |
| At 12 mo | 9.5 (8-11.1) | 11.8 (10.9-12.8) | 16.4 (15.7-17) | 13.9 (13.3-14.5) | |
| At 24 mo | 10.1 (8.5-11.7) | 13.4 (12.3-14.4) | 19.1 (18.4-19.7) | 17.2 (16.6-17.8) |
Data are HR (95% CI).