Figure 3.

Recurrent mutations in DNM2 and SRCAP and genetic pattern in CBF-AML. Lollipop plots indicating localization of mutations and domain structure of DNM2 (A) and SRCAP (B). Each dot represents a single mutation; the corresponding color is the type of mutation. (C) Pairwise associations among genes and cytogenetic abnormalities found in at least 3% of CBF-AML patients. Associations are colored by φ coefficient. P values were adjusted for multiple testing using Benjamini-Hochberg method. Gene pairs that cooccurred more frequently are indicated by blue colors; gene pairs that cooccurred seldom by red colors. Significant associations are marked by asterisks depending on the level of significance.