Figure 2.

Lung MKs are transcriptionally distinct from their hematopoietic counterparts. (A,C) UMAP clustering of MK-lineage clusters from fetal liver (FLiv-1, FLiv-2), fetal lung (Flu), adult BM (ABM-1, ABM-2, ABM-3), and ALu. Fetal and adult lung MKs clustered independently from their hematopoietic counterparts. Numbers in parentheses indicate cell counts for associated clusters. (B,D) Violin plots comparing expression of key MK genes in associated clusters. Key genes used to confirm MK lineage identity are outlined with a dashed box. Colors of violin plots in panels B and D correlate with their respective clusters shown in panels A and C, respectively. *P < .01. (Asterisks indicating significance were withheld from panel B for visual clarity.)