Figure 1.

The diagrammatic illustration of the pathways regulated by H₂S donors in cancer suppression. H₂S donors regulate STAT-3, MAPK, AMPK, PI3K-mTOR, p53, ATM-CHK1/2-CDC25C, NF-кB, and Ras-Raf-Mek-Erk pathways together with the intercellular pH and cell cycle regulators resulting into the inhibition of cell cycle progression and promotion apoptosis. (STAT-3: signal transducer and activator of transcription-3; MAPK: mitogen-activated protein kinase; AMPK: AMP-activated protein kinase; PI3K: phosphoinositide 3-kinase; mTOR: mammalian target of rapamycin; p53: tumor protein 53; ATM: ataxia telangiectasia mutated kinase; CHK1/2: checkpoint kinases 1/2; CDC25C: cell division cycle 25 C protein; NF-кB: nuclear factor-kappa B; Raf: rapidly accelerated fibrosarcoma; ERK: extracellular signal-regulated kinase)