Figure 4.

The diagrammatic presentation of cancer-promoting pathways regulated with NaHS treatment. H₂S donors stimulate HSP90, HIF-1α, AKT, LDHA, JAK-2, MAPK, KATP, cGMP, and NF-қB, but inhibit JNK pathway to exhibit tumor promoting effects. (HSP90: heat shock protein 90; HIF-1α: hypoxia-inducible factor 1 alpha; AKT: protein kinase B; LDHA: lactate dehydrogenase A; JAK-2: Janus kinase 2; MAPK: mitogen-activated protein kinase; KATP: ATP-sensitive potassium channels; cGMP: cyclic guanosine monophosphate; NF-кB: nuclear factor-kappa B; JNK: c-Jun N-terminal kinase).